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KMID : 1189320170110060903
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Asian Spine Journal
2017 Volume.11 No. 6 p.903 ~ p.907
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Effects of Atorvastatin in Patients with Acute Spinal Cord Injury
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Aghazadeh Javad
Motlagh Parviz Samadi
Salehpour Firooz
Meshkini Ali
Fatehi Majid
Mirzaei Farhad
Alavi Seyed Ahmad Naseri
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Abstract
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Study Design: Clinical trial study.
Purpose: The aim of this study was to evaluate the effect of atorvastatin on sensory and motor function in patients with acute spinal cord injury.
Overview of Literature: The prevalence and incidence of traumatic spinal cord injury are increasing. Statins are well established for use in hypercholesterolemia as well as during anti-inflammatory events.
Methods: This clinical trial study included 60 patients with acute spinal cord injury. These were randomly divided into two groups: the case group which received atorvastatin and also underwent surgical therapy and the control group which only underwent surgical therapy.
Results: The severity of spinal cord lesions was evaluated based on the Frankel grade at three periods; this showed no significant difference between the two groups. Comparisons of the levels of pain between the groups based on a Visual Analog Scale system showed no significant difference at the three periods.
Conclusions: We observed no improvement at the 3- and 6-month follow-up in patients who were administered atorvastatin. However, a comparison of the two groups based on pain severity demonstrated a significant difference, suggesting that atorvastatin had a positive effect on patients with spinal cord injury.
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KEYWORD
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Wound and injuries, Spinal cord injuries, Atorvastatin, Pain
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